Dr David Kurtz discusses in this podcast the most recent technical developments and practical applications of circulating tumor DNA and liquid biopsies, an active area of research in the last 25 years, which is now gaining more importance and translational application in the clinic. In tumors like B-cell non-Hodgkin lymphomas, for example, somatic mutations can now be tracked and diagnosed using these techniques. Other fields of active investigations include CLL and solid tumors, as well as disease monitoring and early diagnosis on relapses. Host: Shaun McCann; Guest: Dr. David Kurtz

The whole world of CML changed in the early 2000s with the introduction of imatinib and TKIs, however, the situation in developing countries can be significantly different from Europe and USA, as discussed by Prof Hemant Malhotra in this podcast. Short-backs may encompass the molecular diagnosis and monitoring of the disease (not everywhere available) as well as the cost of drugs and medical expense coverage. On the other hand, the relative affordability of generic TKIs may cause skipping of expensive diagnostic procedures before starting treatment, whereas their current prolonged life expectancy is making the number of CML patients increasingly high. A complex picture that is worth listening to in order to better understand medicine across different regions in the world. Host: Shaun McCann; Guest: Prof. Hemant Malhotra

Transfusion processes have changed significantly in recent years, at the same time changing the guidelines for blood cell replacement therapy. Listen to Prof. Michael Murphy in this podcast as he provides an overview of the most up-to-date topics in transfusion, including the relevant risk of over-transfusion, restricted transfusion practices, and also the issues of delayed transfusion and transfusion-related infections. "Don't give two when one will do," should remain the bottom line criterion in transfusion decisions in stable patients. Host: Shaun McCann; Guest: Prof. Michael Murphy

This podcast follows a short discussion between two young hematologists on a clinical case review of a chronic myeloid leukemia patient called Naomi. In this discussion, the hematologists go through Naomi’s case while addressing the management of CML patients in complete molecular response and the requirements for discontinuation of tyrosine kinase treatment in CML patients. This podcast is rendered from QR Case 5 on the EHA Campus.

In the sixth episode of the Clinical Trial podcast series, Prof. Robert Hills discusses the different reasons that lead to the end of a trial – especially when it is earlier than planned. He also gives us a summary of what happens after the trial; the importance of some steps involving the data and their availability, and the writing of reports for the appropriate regulatory authorities. In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map. It will help you answer interrogations such as: • What is a CRO? • How are clinical studies designed? • Which role(s) should sponsors fulfil? Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts. Host: Prof. Robert Hills

In the fourth episode of the EHA Diagnosing And Treating Iron Deficiency podcast series, host Prof Gunnar Birgegård and guest expert Prof Antonio Almeda discuss the diagnostic and therapeutic management of iron deficiency and anemia in the perioperative setting, a clinical situation where having inadequate iron stores carries significant clinical consequences on mortality and morbidity outcomes. They also address the conclusions of different studies that have investigated the impact of repleting patients with iron on the incidence of complications, mortality, or long-term health. They also disclose how they are monitoring their patients’ iron levels following surgery and why it is important. Host: Prof Gunnar Birgegård; Guest: Prof Antonio Almeda

In the fifth episode of the Clinical Trial podcast series, Prof. Robert Hills discusses the documentation of clinical trials and how it represents a safeguard for the credibility of the trial. He points out the importance of finding a good balance between too many documents and not enough of them. In addition, he highlights the multitude of different groups working on a clinical trial, which ultimately renders documentation an insurance to a smooth process. In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map. It will help you answer interrogations such as: • What is a CRO? • How are clinical studies designed? • Which role(s) should sponsors fulfil? Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts. Host: Prof. Robert Hills

In the fifth and final episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker and guest experts Prof Raul Cordoba, Dr Ulrich Wedding, and Dr Dominique Bron discuss the ethical issues associated with treating hematological malignancies in older adults. They raise different points regarding treatment decisions made with (and not without) the patient and amongst other parameters, how much of an impact costs have in the choice of treatment. Dr Bron also reminds us of the 4 principles of healthcare (nonmaleficence, beneficence, autonomy, and justice) – and that age is not a criterion in deciding whether a patient should be treated or not. Finally, they address the impact of COVID-19 on the current clinical practice and whether it has exacerbated ethical issues. Host: Gareth Tucker; Guest: Prof Raul Cordoba, Dr Ulrich Wedding, Prof Dominique Bron

In the fourth episode of the Clinical Trial podcasts, Dr. Eleftheria Hatzimichael gives us an overview of the sponsor's role and responsibilities in investigator-initiated clinical trials. The different meaning of "sponsor" and "funder", the importance for physicians to be involved in the design of clinical trials, the eight overarching responsibilities of the sponsor, are all key topics discussed in this podcast. In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map. It will help you answer interrogations such as: • What is a CRO? • How are clinical studies designed? • Which role(s) should sponsors fulfil? Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts. Host: Dr. Eleftheria Hatzimichael

In the fourth episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker and guest expert Prof Monica Engelhardt discuss how comprehensive geriatric assessment can guide treatment decisions and improve patient outcomes. Dr Engelhardt gives us an insight into her clinical practice and how elderly hematology patients are receptive - or not - to this testing. You will also learn what are the parameters to consider when treating elderly patients for hematologic malignancies, e.g., how frailty can influence the outcomes of the treatment. Finally, Dr Engelhardt addresses the current pandemic situation regarding these patients: are older patients more vulnerable to COVID-19 when they are already suffering from hematological malignancies and under treatment? Host: Gareth Tucker; Guest: Prof Monika Engelhardt

In the third episode of the Clinical Trial podcasts, Prof. Martin Dreyling from the University of Munich makes several points about standards of care in clinical studies, also mentioned as GCPs (Good Clinical Practices). He gives us a historical perspective on the establishment of these standards 20 years ago, and how they need an update through what he calls a ‘reality check’. Prof. Dreyling is part of the coalition Reducing Bureaucracy in Clinical Trials and explains what they are proposing to update and improve GCPs in 2021. In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map. It will help you answer interrogations such as: • What is a CRO? • How are clinical studies designed? • Which role(s) should sponsors fulfil? Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts. Host: Prof. Martin Dreyling

In the third episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker and experts Prof Antonio Almeida, Prof Valentin Goede, and Dr Annamaria Brioli discuss the treatment of hematological malignancies in older adults, involving polypharmacy in most cases. They describe how patients commonly react to polypharmacy and how challenging it can be to have all the information about a patient’s full list of medication, and to keep them compliant. They also address the step of deprescribing, a critical point in the therapy of these patients. Host: Gareth Tucker; Guest: Prof Valentin Goede, Prof Antonio Almeida, Dr Annamaria Brioli

In the second episode of the Clinical Trial podcasts, former EHA President Prof. John Gribben gives us an overview of the role(s) of CROs (Contract Research Organizations) in clinical investigation. He discusses how they can help, notably with the paper trails associated with clinical trials, and how they should be constructive partners in the process of clinical research. In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map. It will help you answer interrogations such as: • What is a CRO? • How are clinical studies designed? • Which role(s) should sponsors fulfil? Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts. Host: Prof. John Gribben

In the second episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker discusses with experts Prof Alessandra Tucci and Prof Sergio Storti the definition and importance of patient assessment (including frailty, comorbidity, and polypharmacy), in older adults with hematological conditions and how it can be used to determine the overall ‘fitness’ of a patient. They also discuss the critical role of interactions between HCPs, patients, and their entourage in the assessment. You will listen to clinical examples showing how a complete geriatric assessment can help direct treatment for older patients with specific hematological malignancies and how a benefit can be obtained from more effective, novel treatments. Host: Gareth Tucker; Guest: Prof Alessandra Tucci, Prof Sergio Storti

In this podcast, the last of a series dedicated to Multiple Myeloma in underserved patient populations with, Prof Sonja Zweegman focuses on the challenges associated with MM treatment in older patients, namely the assessment of frailty and how to adapt treatment in this population. The podcast also addresses the specific characteristics of MM in the elderly, including the incidence of genetic mutations and the role of comorbidities. Speaker: Prof Sonja Zweegman; Host: Prof Pieter Sonneveld

In the first episode of the Clinical Trial podcasts, Amsterdam UMC researcher and author of “A Quick Guide on How to Conduct Medical Research” Dr. Marieke Ter Wee points out the importance of formulating a research question at the beginning of any clinical trial. What models are used to formulate the question and answer to it? She unravels the main parts of a research proposal that should be elaborated by the authors of clinical studies. In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map. It will help you answer interrogations such as: • What is a CRO? • How are clinical studies designed? • Which role(s) should sponsors fulfil? Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts. Host: Dr. Marieke ter Wee

In the Aging Patient: Dispelling Myths podcast series, Prof Raul Cordoba kicks off a series of podcasts that will offer you up-to-date information about hematology in older adults. For the first interview, he welcomes guest expert Dr Kristina Kirschner to discuss aging and clonal disease. You will learn how clonal hematopoiesis increases with advancing age and how the accumulation of some clonal mutations have been linked with hematological cancers. Dr Kirschner answers questions - asked by patients - about the definition of aging by hematologists, or the relation of aging and susceptibility to clonal cancers. They also address the mechanisms of epigenetic mutations in aging hematopoietic stem cells and the impact of genes drivers of myeloid malignancies in the elderly population. Host: Dr Raul Cordoba; Guest: Dr Kristina Kirschner

In the third episode of the EHA Diagnosing And Treating Iron Deficiency podcast series, host Prof Gunnar Birgegård and guest expert Dr Noemi Roy review the many important functions iron plays in the body, providing the background for the high prevalence of iron deficiency in women, particularly in their fertile life and during pregnancies. They address different strategies of treatment, including IV, oral treatment, and nutrition recommendations. Finally, they also highlight the importance of treating iron deficiency after childbirth when the mother comes back home. Host: Prof Gunnar Birgegård; Guest: Dr Noemi Roy

In the second episode of the EHA Diagnosing And Treating Iron Deficiency podcast series, host Prof Gunnar Birgegård and guest expert Prof Christopher Winearls highlight the high prevalence of iron deficiency anemia in patients with CKD, together with its association with poor long-term outcomes. They discuss the importance of monitoring iron on top of monitoring erythropoietin and treating the deficiency prior to the use of erythropoietin. Overall, Prof Winearls discloses how to evaluate ferritin and Hb levels in CKD patients and how to treat iron deficiency and monitor outcomes in this special population. Host: Prof Gunnar Birgegård; Guest: Prof Christopher Winearls

In the first episode of the EHA Diagnosing And Treating Iron Deficiency podcast series, Prof Gunnar Birgegård and host expert Prof Antonio Almeida define what is iron deficiency and more precisely functional iron deficiency. They discuss the prevalence of anemia in cardiac failure patients and the relation between severity of the heart disease and incidence of iron deficiency. They also highlight the importance of monitoring potential renal symptoms for better treatment outcomes. Host: Prof Gunnar Birgegård; Guest: Prof Antonio Almeida This episode was produced with the support of the World Heart Federation.

In episode 9 of "EHA Unplugged", Prof. Shaun McCann describes the importance of general medical management in multiple myeloma (MM) patients and the application of the principles of treatment in different subpopulations of patients. He also explains how to diagnose MM and assess the response to treatment.

This podcast, the second of a series dedicated to Multiple Myeloma in underserved populations, addresses clinical challenges in MM, with a focus on high-risk disease and cytogenetics. Prof Weisel describes the established genetic prognostic markers in MM, and the new abnormalities that are becoming important, besides the role and impact of Minimal Residual Disease (MRD) on risk status and classification of MM patients. Speaker: Prof Katja Weisel; Host: Prof Pieter Sonneveld

In episode 8 of "EHA Unplugged", Prof. Shaun McCann details the diagnostic and prognostic criteria of CLL and the correct diagnostic work-up. He also describes the increasing array of treatments available for CLL patients and outlines the role of allogeneic transplantation in this disease.

In episode 7 of "EHA Unplugged", Prof. Shaun McCann describes the clinical and genetic features of chronic myeloid leukemia (CML), discusses the best therapeutic options, and characterizes the changes that occur in the natural history of the disease after the introduction of tyrosine-kinase inhibitors (TKIs).

This podcast series brings together people affected by SCD and specialist hematologists to shed light on this widely misunderstood condition, bringing the guidelines to life and helping healthcare professionals improve their practice by understanding the patient experience. In this closing discussion, Dr Jo Howard and Professor Léon Tshilolo reflect on what they have learned from their conversations with people affected by sickle cell disease and sickle cell trait, and discuss the present and future of sickle cell disease treatment across the world. SCD: What Physicians Can Learn From Patients And Carriers is a three-episode podcast series with the first one created to mark Black History Month 2021. It is a collaboration between EHA and Obsidian Healthcare Group, a global provider of medical education. Interview with: Dr Jo Howard and Professor Léon Tshilolo Host: Mandi Watty-Miller

In this podcast, the first of a series dedicated to Multiple Myeloma in underserved patient populations, Prof Terpos illustrates the impact of renal disease on MM outcomes and how it should best be managed. Follow the podcast to learn about assessment and monitoring of renal function in MM patients, the available treatment options for this population, and the role and outcomes of kidney transplantation. Speaker: Prof Evangelos Terpos; Host: Prof Pieter Sonneveld

This podcast series brings together people affected by SCD and specialist hematologists to shed light on this widely misunderstood condition, bringing the guidelines to life and helping healthcare professionals improve their practice by understanding the patient experience. In the second episode, a mother and daughter affected by sickle cell are joined by hematologist Professor Léon Tshilolo for an interview with Mandi Watty-Miller, an individual with sickle cell trait. They discuss the experience of raising a child with sickle cell disease, navigating the world of online misinformation about the condition, and how to improve communication and trust between doctors and patients. SCD: What Physicians Can Learn From Patients And Carriers is a three-episode podcast series with the first one created to mark Black History Month 2021. It is a collaboration between EHA and Obsidian Healthcare Group, a global provider of medical education. Interview with: Prof Léon Tshilolo Host: Mandi Watty-Miller

In this podcast, Dr. Rijneveld discusses BCR-ABL1-like acute lymphoblastic leukemia (ALL), a specific subgroup of ALL characterized by an expression profile similar to Ph+ ALL, albeit lacking the BCR-ABL1 rearrangement, and by sensitivity to TKIs. She highlights how TKIs were game-changing for the prognostic of these patients, although their cost and associated toxicities (usually low but fatiguing in the long-term), may still be issues in the clinical practice. Interview with: Anita Rijneveld. Host: Shaun McCann

Listen to this expert interview to discover characteristics and outcomes of acute lymphoblastic leukemia (ALL) in adults and children. Dr Advani guides us in the biology and genetics of the disease in these two categories of patients, dedicating a special focus to Philadelphia-like ALL and to the clinical and prognostic role of measurable residual disease (MRD). Finally, as CAR-T therapies are becoming available to adult ALL patients, challenges and promises of this approach are discussed in the concluding part of the podcast. Interview with: Anjali Advani. Host: Shaun McCann

In this podcast, Dr Nemeth reminds us that iron is not only necessary for hematopoiesis and red cell production. A complex relationship exists between iron levels and susceptibility to infections, which involves the different sensibility of microbes to iron as well as the association between iron deficiency and poor response to immunization, as you will discover in this clear overview on the role of iron in host defence. Interview with: Elizabeta Nemeth. Host: Ayan Panjan

This podcast series brings together people affected by SCD and specialist hematologists to shed light on this widely misunderstood condition, bringing the guidelines to life and helping healthcare professionals improve their practice by understanding the patient experience. In this first episode, consultant hematologist Dr Jo Howard has a conversation with two individuals affected by sickle cell disease (SCD) and sickle cell trait (SCT). They discuss the impact that the condition has on their personal and family lives, common misconceptions about the SCD experience, areas where treatment frequently falls short, and how to raise awareness further. SCD: What Physicians Can Learn From Patients And Carriers is a three-episode podcast series with the first one created to mark Black History Month 2021. It is a collaboration between EHA and Obsidian Healthcare Group, a global provider of medical education. Host: Dr Jo Howard

Listen to this podcast to hear a psychologist’s point of view on sickle cell disease (SCD), and how to address the psychological as well as the hematological needs of SCD patients. The importance of specific psychological support services for SCD patients, the concept of social stigmatization as a true complication of the disease, and its consequences for physicians dealing with these patients are discussed in this podcast. Interview with: Kofi Anie. Host: Ayan Panjan

This podcast focuses on the social aspects of SCD, in particular on the challenges confronting adolescents with SCD and their treating physicians. Prof. Hankins speaks about the delicate transition from pediatric to adult care, the use of technology in improving the care of these patients, and the issues associated with access to new treatments. Interview with: Jane Hankins. Host: Shaun McCann

In this podcast, Dr Smith-Whitley illustrates the many different aspects and possible pregnancy complications for mother and fetus in women with SCD. Practical aspects dealt within the clinical practice, such as the management of pain in the pregnant woman, use of transfusions and HU, and reproductive education for SCD patients, are also discussed in the podcast. Interview with: Kim Smith-Whitley. Host: Shaun McCann

In episode 6 of "EHA Unplugged", Prof. Shaun McCann discusses Paroxysmal Nocturnal Hemoglobinuria. You will hear him describe the etiology and the clinical manifestations of paroxysmal nocturnal hemoglobinuria (PNH), apply the correct diagnostic work-up if the disease is suspected, and discuss the principles of treatment in these patients, including monoclonal antibodies and HCT.

In episode 5 of "EHA Unplugged", Prof. Shaun McCann discusses HSCT in Severe Aplastic Anemia. You will hear him detail the diagnostic criteria of severe aplastic anemia (SAA) and the current therapeutic approaches for this disease. He will also characterize the results of HCT, the best conditioning options and different source of hemopoietic cells for SAA patients.

In episode 4 of "EHA Unplugged", Prof. Shaun McCann discusses the phenomenon of engraftment and chimerism following hemopoietic cell transplantation (HCT) and the main techniques used to determine the origin of the cells in the recipient.

In episode 3 of "EHA Unplugged", Prof. Shaun McCann talks about infections in HSCT.

In episode 2 of "EHA Unplugged", Prof. Shaun McCann explains the relationship between HSCT and graft-versus-host disease.

In episode 1 of "EHA Unplugged", Prof. Shaun R McCann is describing the history of HSCT.